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肝细胞癌是全球发病率高且致死率较高的常见恶性肿瘤之一。90钇微球选择性内放射治疗(90Y-SIRT)作为一种局部精准放射介入治疗手段,适用于各个阶段的肝细胞癌患者。然而,其疗效和安全性高度依赖于微球的精准靶向输送和剂量分布。多模态影像整合解剖、功能、代谢等多维影像信息,实现从术前规划、术中导航到术后评估的全过程可视化与定量化管理。术前影像融合有助于个体化患者筛选和剂量模拟,术中影像指导导管精准定位与实时灌注验证,术后影像评估微球分布、疗效反应及并发症监测。多模态影像的深度融合显著提升了90Y-SIRT的精准性与安全性。本综述总结并讨论了当前多模态影像在90Y-SIRT中的临床应用与技术进展,强调其在治疗流程中的实际价值。
Abstract:Hepatocellular carcinoma is one of the most common malignancies with a high incidence and mortality worldwide.Yttrium-90 microsphere selective internal radiation therapy(90Y-SIRT) is a localized and precise radio-interventional therapy method,which is suitable for patients with all stages of hepatocellular carcinoma. However, its efficacy and safety are highly dependent on the accurate targeted delivery of microspheres and dose distribution. Multimodal imaging integrates anatomical, functional, metabolic and other imaging information to visualize and quantify during the whole process from preoperative planning, intraoperative navigation to postoperative evaluation. Preoperative image fusion is helpful for individualized patient selection and dose simulation. Intraoperative images guide accurate catheter positioning and real-time perfusion verification. Postoperative images allow evaluation of the distribution of microspheres, therapeutic response and complication. Integration of multimodal images significantly improves the accuracy and safety of90Y-SIRT. This review summarizes and discusses the current applications and technical progress of multimodal imaging in90YSIRT and emphasizes its practical value in the treatment process.
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基本信息:
中图分类号:R735.7
引用信息:
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