影像诊断与介入放射学

目的评价聚桂醇在单纯性肝肾囊肿硬化治疗中的应用价值。方法将65例单纯性肝肾囊肿患者随机分成两组,无水乙醇组33例(35个囊肿)抽尽囊液后,用无水乙醇反复冲洗,直至回抽的液体颜色由乳白色完全变清,抽净无水乙醇,聚桂醇组32例(32个囊肿)患者抽尽囊液后,按抽出囊液体积1/10¹/4的比例注入聚桂醇并留置囊内。治疗过程中观察患者的反应,详细记录患者主诉,所有患者术后1、3、6月复查超声。结果 6个月后,2组治愈率,有效率及不良反应发生率分别为62.9%,94.3%,45.5%;65.6%,96.8%,9.4%,两组治愈率及总有效率无显著差异(P>0.05),不良反应发生率差异有统计学意义(P<0.01)。结论聚桂醇作为一种新型硬化剂,在肝肾囊肿硬化治疗中是安全的、有效的,值得在临床推广应用。

Objective To evaluate the safety and efficacy of polidocanol sclerotherapy of simple hepatic and renal cysts. Methods Sixty-five patients were randomized and treated with anhydrous alcohol(33 patients with 35 cysts) or polidocanol(32 patients with 32 cysts).After aspirating the cyst content,the cavity was irrigated repeatedly with alcohol until the fluid was clear.The alcohol was then completely aspirated.With polidocanol sclerotherapy,as much as 10%-25%of the aspirated cyst fluid was re-injected into the cavity.Any adverse reactions were recorded and all patients underwent follow-up ultrasound examinations at 1,3,and 6 months. Results At 6 months after sclerotherapy,there was no significant difference in the cure rates(62.9%,65.6%) and effectiveness rates(94.3%,96.8%) between anhydrous alcohol and polidocanol(P > 0.05) whereas adverse reactions from anhydrous alcohol(51.4%) were significantly(P < 0.01) more frequent than those from polidocanol(6.3%).Conclusions Polidocanol is an effective and safe sclerosing agent for simple hepatic and renal cysts.